Thyroid Zen Defense

Name: Thyroid Zen Defense
Brand: Allergy Research Group
SKU: ARG-77555
Price: 57.79 USD
Availability: InStock

$57.79 USD

120 capsules

Thyroid Zen Defense is designed to support three key pathways for maintaining healthy thyroid and immune function.* This advanced formula features Holixer® Holy basil extract, clinically studied for its ability to promote cortisol balance and a healthy stress response, both of which are vital for maintaining thyroid health.* A combination of selenium and myo-inositol, included in a clinically-supported ratio, work together to promote thyroid hormone production, cellular function, and overall endocrine balance.* Time-honored shiitake mushroom extract is included to enhance immune resilience and help maintain healthy immune function by supporting natural killer (NK) cell activity and immunomodulation. With its blend of clinically supported and traditional ingredients, Thyroid Zen Defense offers a multi-mechanistic approach to maintaining optimal thyroid, mood, and immune health.

Pairs Well With

Thyroid Zen Defense

$57.79 USD

Key Benefits

Targeted Thyroid and Stress Response Support with Adaptogens and Immune-Modulating Nutrients*

What It Does
This formula delivers clinically studied nutrients and botanicals that support thyroid function, stress resilience, and immune system balance.* It targets the intersection of the hypothalamic-pituitary-thyroid (HPT) axis and stress physiology to promote healthy hormone synthesis, immune surveillance, and adaptive responses.*

How It Works
• Holy Basil (Holixer® extract): Clinically shown to reduce perceived stress and support cortisol balance, this adaptogen helps buffer stress-related disruptions to the HPT axis.*[1]
• Myo-Inositol + Selenium: In combination, this duo has been shown in multiple trials to support thyroid hormone biosynthesis and regulation more effectively than selenium alone.*[2–5]
• Myo-Inositol: Supports iodine uptake and organification, essential for thyroid hormone production in thyrocytes.*[4]
• Selenium: A cofactor for deiodinase and antioxidant enzymes (glutathione peroxidases, thioredoxin reductases), selenium protects thyroid tissue from oxidative stress and modulates immune signaling.*[5–7]
• Shiitake Mushroom (Lentinula edodes): Provides immunomodulatory beta-glucans and polysaccharides that influence natural killer (NK) cell activity, supporting immune surveillance and thyroid-immune interaction.*[8,9]
• Immune-Thyroid Interactions: NK cell activity plays a regulatory role in thyroid function, particularly during aging and times of immune activation.*[10]

Who It’s For
Designed for individuals seeking stress resilience and thyroid balance, particularly those seeking optimal thyroid health, stress response balance, or immune-thyroid axis support.*

Special Features
Provides a cohesive formula aimed at the triad of stress, thyroid, and immune health.*

References
1. Lopresti AL, et al. Front Nutr. 2022;9:965130. doi:10.3389/fnut.2022.965130
2. Ferrari SM, et al. Eur Rev Med Pharmacol Sci. 2017;21(2 Suppl):36–42.
3. Pace C, et al. Endocr J. 2020;67(11):1093–1098.
4. Paparo SR, et al. Front Endocrinol (Lausanne). 2022;13:930756. doi:10.3389/fendo.2022.930756
5. Nordio M, Basciani S. Eur Rev Med Pharmacol Sci. 2017;21(2 Suppl):51–59.
6. Wang F, et al. Front Endocrinol (Lausanne). 2023;14:1133000. doi:10.3389/fendo.2023.1133000
7. Pirola I, et al. Endocrinol Diabetes Nutr (Engl Ed). 2020;67(1):28–35.
8. Bisen PS, et al. Curr Med Chem. 2010;17(22):2419–2430.
9. Roszczyk A, et al. Int J Mol Sci. 2022;23(16):8980. doi:10.3390/ijms23168980
10. Lee EK, Sunwoo JB. Endocrinol Metab (Seoul). 2019;34(2):132–137

Suggested Use

As a dietary supplement, take 2 capsules twice daily, or as directed by a healthcare practitioner.

Warnings

If you are pregnant or lactating, have any health conditions or are taking any medication, consult your healthcare practitioner before use. Store in a cool, dry place, tightly capped, away from light. Keep out of the reach of children. Use only if safety seal is intact. Variations in product color may occur.

Dietary Preferences

Dairy-free
Gluten-free
Soy-free

Supplement Facts

Serving Size: 2 capsules

Servings Per Container: 60

Amount Per Serving	% Daily Value
Selenium (as L-selenomethionine)	83 mcg	150%
Myo-Inositol	600 mg	†
Holy Basil Extract (as Holixer™ Ocimum sanctum leaf extract standardized to >5% Ocimum Bioactive Complex)	125 mg	†
Shiitake Extract 4:1 (Lentinula edodes fruiting body)	500 mg	†
*Daily Value not established.

Other Ingredients: Hydroxypropyl methylcellulose, microcrystalline cellulose, magnesium stearate, silicon dioxide.

‡Disclaimer: These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.

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