B12 Adenosylcobalamin 3000 mcg with Folate

Support Mitochondrial Energy and Neurological Health with a High-Potency, Bioactive B12 Formula*

What It Does
B12 Adenosylcobalamin 3000 mcg with Folate supports cellular energy production, healthy nerve structure and function, and optimal red blood cell formation.* This advanced formula contributes to balanced methylation, neurotransmitter synthesis, and homocysteine metabolism for metabolic and cognitive well-being.*

How It Works
• Adenosylcobalamin (active B12, 3000 mcg): Directly supports mitochondrial energy production by facilitating the conversion of methylmalonyl-CoA to succinyl-CoA in the citric acid cycle, essential for ATP synthesis.*[1,4,11]
• Folate: Supports normal methylation and neurotransmitter synthesis, while also working in tandem with vitamin B12 to support homocysteine levels and red blood cell production.*[1,8,9]
• Vitamin B12 (as adenosylcobalamin): Essential for myelin sheath integrity, supporting nerve conduction, emotional health, and cognitive function, especially in the aging population or those on medications that affect vitamin B12 absorption.*[2,3,5,7,10]
• High-dose oral vitamin B12: Shown in systematic reviews to be useful for improving B12.*[11]

Who It’s For
Ideal for individuals with increased need for bioactive B12, such as those following vegetarian or vegan diets, older adults, or those seeking to optimize their vitamin B12 status.*

Special Features
Provides a neurologically active, mitochondrial-ready form of B12 in lozenge format to support optimal absorption.

References
1. Baltrusch S. Biomed Res Int. 2021;2021:9968228. doi:10.1155/2021/9968228
2. Pawlak R, et al. Eur J Clin Nutr. 2014;68(5):541–548.
3. Lachner C, et al. J Neuropsychiatry Clin Neurosci. 2012;24(1):5–15.
4. Mumtaz H, et al. Ann Med Surg (Lond). 2022;82:104762. doi:10.1016/j.amsu.2022.104762
5. Infante M, et al. World J Diabetes. 2021;12(7):916–931.
6. Ueno A, et al. Nutrients. 2022;14(7):1494. doi:10.3390/nu14071494
7. Sangle P, et al. Cureus. 2020;12(10):e11169. doi:10.7759/cureus.11169
8. Syed EU, et al. Open Neurol J. 2013;7:44–48.
9. Calderon-Ospina CA, Nava-Mesa MO. CNS Neurosci Ther. 2020;26(1):5–13.
10. Beaudry-Richard A, et al. Ann Neurol. doi:10.1002/ana.27200
11. Wang H, et al. Cochrane Database Syst Rev. 2018;3(3):CD004655. doi:10.1002/14651858.CD004655.pub3